Exploratory Analysis of Single Nucleotide Polymorphism (SNP) for Quantitative Traits
نویسندگان
چکیده
منابع مشابه
Single nucleotide polymorphism (SNP) analysis of mouse quantitative trait loci for identification of candidate genes.
M ouse models are widely used for studying polygenic traits underlying various diseases to identify the low penetrance disease susceptibility genes. Classical genetic studies using cross breeding of mouse strains with differing susceptibilities to different diseases have identified chromosomal regions associated with predisposition to lung tumours, lung injury, disease resistance, and seizure. ...
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Background Single nucleotide polymorphism (SNPs) are considered as one of the underlying causes of male infertility. Proper sperm chromatin packaging which involves replacement of histones with protamines has profound effect on male fertility. Over 20 SNPs have been reported for the protamine 1 and 2. MaterialsAndMethods The aim of this study was to evaluate the frequency of two previously repo...
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High-resolution melting of polymerase chain reaction (PCR) products can detect heterozygous mutations and most homozygous mutations without electrophoretic or chromatographic separations. However, some homozygous single nucleotide polymorphism (SNPs) have melting curves identical to that of the wild-type, as predicted by nearest neighbor thermodynamic models. In these cases, if DNA of a known r...
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A facile, rapid, stable and sensitive approach for fluorescent detection of single nucleotide polymorphism (SNP) is designed based on DNA ligase reaction and π-stacking between the graphene and the nucleotide bases. In the presence of perfectly matched DNA, DNA ligase can catalyze the linkage of fluorescein amidite-labeled single-stranded DNA (ssDNA) and a phosphorylated ssDNA, and thus the for...
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Dear Editor, The recent article by Mohammadzadeh et al.[1] on the latest issue of this Journal showed that the T allele +276G/T SNP of ADIPOQ gene is more associated with the increasing risk of coronary artery disease (CAD) in subjects with type 2 diabetes. Adipocytes were described in myocardial tissue of CAD patients and their role recently discussed[2,3]. Susceptibility to CAD by polymorp...
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ژورنال
عنوان ژورنال: The Stata Journal: Promoting communications on statistics and Stata
سال: 2005
ISSN: 1536-867X,1536-8734
DOI: 10.1177/1536867x0500500201